Following medical school at Tulane and a radiology residency at Ochsner Clinic Foundation in New Orleans, he completed a fellowship in Breast Imaging at the University of Chicago in 1995. From 2003-2009, Dr Comstock was the Director of Breast Imaging at the University of California at San Diego and completed a 2 year ACRIN fellowship in clinical trials in medical imaging. From 2009-2024, he was an Attending radiologist at Memorial Sloan-Kettering Cancer Center in New York. Dr Comstock became a Fellow of the American College of Radiology in 2012. His past professional service includes Chair of the ACR Breast Ultrasound Accreditation program, Chair of the RSNA Breast Refresher Course program, Chair of the ACR Breast Commission on Breast Imaging BI-RADS Lexicon Subcommittee on MRI, and Breast Committee Imaging Co-Chair of the ECOG-ACRIN NCI co-operative group. His prior research studies include serving as the Co-PI of the Alliance A011104/ACRIN 6694 study, Effect of Preoperative Breast MRI on Surgical Outcomes, and study chair of the ECOG-ACRIN (EA1141), Comparison of Abbreviated Breast MRI and Digital Breast Tomosynthesis. He is study chair of active CMIST (Contrast Enhanced Mammography Imaging Screening Trial), a multicenter trial comparing DBT and contrast enhanced mammography and co-PI of the planned University of California at Davis/ACR study, Supplemental Yield and Performance of Smart Abbreviated Breast MRI.